Publications

Julian Peter Müller, Jens Sarömba, Patrick Ziegler, Roman Tremmel, Jens Rengelshausen, Elke Schaeffeler, Katja S Just, Matthias Schwab, Thomas Kraus, Julia C Stingl (2023). Nutrimetric Validation of Solanidine as Dietary-Derived CYP2D6 Activity Marker In Vivo. Clin Pharmacol Ther 2023 Nov.

Roman Tremmel, Sebastian Pirmann, Yitian Zhou, Volker M Lauschke (2023). Translating pharmacogenomic sequencing data into drug response predictions-How to interpret variants of unknown significance. Br J Clin Pharmacol 2023 Sep.

Roman Tremmel, Yitian Zhou, Matthias Schwab, Volker M Lauschke (2023). Structural variation of the coding and non-coding human pharmacogenome. NPJ Genom Med 2023 Sep;8(1).

Roman Tremmel, Ute Hofmann, Mathias Haag, Elke Schaeffeler, Matthias Schwab (2023). Circulating Biomarkers Instead of Genotyping to Establish Metabolizer Phenotypes. Annu Rev Pharmacol Toxicol 2023 Aug.

Jesse J Swen, Cathelijne H van der Wouden, Lisanne En Manson, Heshu Abdullah-Koolmees, Kathrin Blagec, Tanja Blagus, Stefan Böhringer, Anne Cambon-Thomsen, Erika Cecchin, Ka-Chun Cheung, Vera Hm Deneer, Mathilde Dupui, Magnus Ingelman-Sundberg, Siv Jonsson, Candace Joefield-Roka, Katja S Just, Mats O Karlsson, Lidija Konta, Rudolf Koopmann, Marjolein Kriek, Thorsten Lehr, Christina Mitropoulou, Emmanuelle Rial-Sebbag, Victoria Rollinson, Rossana Roncato, Matthias Samwald, Elke Schaeffeler, Maria Skokou, Matthias Schwab, Daniela Steinberger, Julia C Stingl, Roman Tremmel, Richard M Turner, Mandy H van Rhenen, Cristina L Dávila Fajardo, Vita Dolžan, George P Patrinos, Munir Pirmohamed, Gere Sunder-Plassmann, Giuseppe Toffoli, Henk-Jan Guchelaar (2023). A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. Lancet 2023 Feb;401(10374):347-356.

Lu Pan, Shaobo Shan, Roman Tremmel, Weiyuan Li, Zehuan Liao, Hangyu Shi, Qishuang Chen, Xiaolu Zhang, Xuexin Li (2023). HTCA: a database with an in-depth characterization of the single-cell human transcriptome. Nucleic Acids Res 2023 6 Jan;Pages D1019–D1028.

Filippa Schreeck, Gabriele Ahne, Roman Tremmel, Elke Schaeffeler, Matthias Schwab (2022). Pharmacogenomics in pediatric medicine and drug development. Pharmacogenomics 2022 Aug;23(13).

Yitian Zhou, Roman Tremmel, Elke Schaeffeler, Matthias Schwab, Volker M Lauschke (2022). Challenges and opportunities associated with rare-variant pharmacogenomics. Trends Pharmacol Sci 2022 Aug;43(10).

Simon Jäger, Martin Wohlrab, Daniel Schoene, Roman Tremmel, Michael Chambers, Solange Corriol-Rohou, Jochen Klenk, Basil Sharrack, Judith Garcia-Aymerich, Lynn Rochester, Walter Maetzler, Milo Puhan, Matthias Schwab, Clemens Becker (2022). Mobility endpoints in marketing authorisation of drugs: what gets the European medicines agency moving?. Age Ageing 2022 Jan 6;51(1).

Cornelis M van Tilburg, Elke Pfaff, Kristian W Pajtler, Karin P S Langenberg, Petra Fiesel, Barbara C Jones, Gnana Prakash Balasubramanian, Sebastian Stark, Pascal D Johann, Mirjam Blattner-Johnson, Kathrin Schramm, Nicola Dikow, Steffen Hirsch, Christian Sutter, Kerstin Grund, Arend von Stackelberg, Andreas E Kulozik, Andrej Lissat, Arndt Borkhardt, Roland Meisel, Dirk Reinhardt, Jan-Henning Klusmann, Gudrun Fleischhack, Stephan Tippelt, Dietrich von Schweinitz, Irene Schmid, Christof M Kramm, Andre O von Bueren, Gabriele Calaminus, Peter Vorwerk, Norbert Graf, Frank Westermann, Matthias Fischer, Angelika Eggert, Birgit Burkhardt, Wilhelm Wößmann, Michaela Nathrath, Stefanie Hecker-Nolting, Michael C Frühwald, Dominik T Schneider, Ines B Brecht, Petra Ketteler, Simone Fulda, Ewa Koscielniak, Michael T Meister, Monika Scheer, Simone Hettmer, Matthias Schwab, Roman Tremmel, Ingrid Øra, Caroline Hutter, Nicolas U Gerber, Olli Lohi, Bernarda Kazanowska, Antonis Kattamis, Maria Filippidou, Bianca Goemans, C Michel Zwaan, Till Milde, Natalie Jäger, Stephan Wolf, David Reuss, Felix Sahm, Andreas von Deimling, Uta Dirksen, Angelika Freitag, Ruth Witt, Peter Lichter, Annette Kopp-Schneider, David T W Jones, Jan J Molenaar, David Capper, Stefan M Pfister, Olaf Witt (2021). The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets. Cancer Discov 2021 Aug;11(11).

Simon Jäger, Severin Schricker, Roman Tremmel, Elke Schaeffeler, Matthias Schwab (2021). Pharmacogenetic diagnostics to improve drug therapy in clinical practice. Dtsch Med Wochenschr 2021 Jan;146(1).

Simon Jäger, Severin Schricker, Roman Tremmel, Elke Schaeffeler, Matthias Schwab (2021). How to manage polypharmacia?. Dtsch Med Wochenschr 2021 Jan;146(1).

Ute A Schwinghammer, Magda M Melkonyan, Lilit Hunanyan, Roman Tremmel, Ralf Weiskirchen, Erawan Borkham-Kamphorst, Elke Schaeffeler, Torgom Seferyan, Wolfgang Mikulits, Konstantin Yenkoyan, Matthias Schwab, Lusine Danielyan (2020). α2-Adrenergic Receptor in Liver Fibrosis: Implications for the Adrenoblocker Mesedin.. Cells 2020 Feb;9(2).

Roman Tremmel, Kathrin Klein, Florian Battke, Sarah Fehr, Stefan Winter, Tim Scheurenbrand, Elke Schaeffeler, Saskia Biskup, Matthias Schwab, Ulrich M Zanger (2019). Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression.. Hum Genet 2019 Nov;139(2).

Emaad Abdel-Kahaar, Stefan Winter, Roman Tremmel, Elke Schaeffeler, Christoph J Olbricht, Eberhard Wieland, Matthias Schwab, Maria Shipkova, Simon U Jaeger (2019). The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center. Front Genet 2019 Sep;10.

Kathrin Klein, Roman Tremmel, Stefan Winter, Sarah Fehr, Florian Battke, Tim Scheurenbrand, Elke Schaeffeler, Saskia Biskup, Matthias Schwab, Ulrich M Zanger (2019). A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort. Front Genet 2019 Jan;10.

Anca Florian, Alexandru Patrascu, Roman Tremmel, Sabine Rösch, Udo Sechtem, Matthias Schwab, Elke Schaeffeler, Ali Yilmaz (2018). Identification of Cardiomyopathy-Associated Circulating miRNA Biomarkers in Muscular Dystrophy Female Carriers Using a Complementary Cardiac Imaging and Plasma Profiling Approach. Front Physiol 2018 Dec;9.

Simon U Jaeger, Elke Schaeffeler, Stefan Winter, Roman Tremmel, Jürgen Schölmerich, Nisar Malek, Eduard F Stange, Matthias Schwab, Jan Wehkamp (2018). Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease. Front Pharmacol 2018 Jul;9.

Charlotta Pauline Irmgard Schärfe, Roman Tremmel, Matthias Schwab, Oliver Kohlbacher, Debora Susan Marks (2017). Genetic variation in human drug-related genes.. Genome Med 2017 Dec;9(1).

Roman Tremmel, Kristin Herrmann, Wolfram Engst, Walter Meinl, Kathrin Klein, Hansruedi Glatt, Ulrich M Zanger (2017). Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels.. Arch Toxicol 2017 Mar;91(10).

R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler (2017). Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies.. Clin Pharmacol Ther 2017 Feb;101(5).

Barbara C Worst, Cornelis M van Tilburg, Gnana Prakash Balasubramanian, Petra Fiesel, Ruth Witt, Angelika Freitag, Miream Boudalil, Christopher Previti, Stephan Wolf, Sabine Schmidt, Sasithorn Chotewutmontri, Melanie Bewerunge-Hudler, Matthias Schick, Matthias Schlesner, Barbara Hutter, Lenka Taylor, Tobias Borst, Christian Sutter, Claus R Bartram, Till Milde, Elke Pfaff, Andreas E Kulozik, Arend von Stackelberg, Roland Meisel, Arndt Borkhardt, Dirk Reinhardt, Jan-Henning Klusmann, Gudrun Fleischhack, Stephan Tippelt, Uta Dirksen, Heribert Jürgens, Christof M Kramm, Andre O von Bueren, Frank Westermann, Matthias Fischer, Birgit Burkhardt, Wilhelm Wößmann, Michaela Nathrath, Stefan S Bielack, Michael C Frühwald, Simone Fulda, Thomas Klingebiel, Ewa Koscielniak, Matthias Schwab, Roman Tremmel, Pablo Hernáiz Driever, Johannes H Schulte, Benedikt Brors, Andreas von Deimling, Peter Lichter, Angelika Eggert, David Capper, Stefan M Pfister, David T W Jones, Olaf Witt (2016). Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.. Eur J Cancer 2016 Jul;65.

Lucia Pellé, Monica Cipollini, Roman Tremmel, Cristina Romei, Gisella Figlioli, Federica Gemignani, Ombretta Melaiu, Chiara De Santi, Elisa Barone, Rossella Elisei, Eric Seiser, Federico Innocenti, Ulrich M Zanger, Stefano Landi (2016). Association between CYP2E1 polymorphisms and risk of differentiated thyroid carcinoma.. Arch Toxicol 2016 Jan;90(12).

R Tremmel, K Klein, S Winter, E Schaeffeler, U M Zanger (2015). Gene copy number variation analysis reveals dosage-insensitive expression of CYP2E1.. Pharmacogenomics J 2015 Oct;16(6).

U M Zanger, K Klein, M Thomas, J K Rieger, R Tremmel, B A Kandel, M Klein, T Magdy (2013). Genetics, epigenetics, and regulation of drug-metabolizing cytochrome p450 enzymes.. Clin Pharmacol Ther 2013 Nov;95(3).